Absolutely nothing changes about how I interview. I care whether you are “smart and gets things done”.
“Tell me about the project that you are most proud of?” And then dig in and asking them about their challenges decision making processes, and gauge the level of scope, impact and ambiguity they know how to work at.
“I see you have been working for $x years. Knowing what you know now, what would you do differently?”
“Say you are in a meeting with myself, the CEO and other senior developers who have been at the company for awhile and we all agree on an idea that in your experience you know is a bad idea, what would you do?”
Follow up question: “What would you do if after we listened to you, we decided to go in another direction?”
“Tell me about a time when you had unclear requirements , how did you handle it?” - gets back to ambiguity. There is a lot of that with startups.