NMDA Receptor Antagonists: Slightly More Than You Wanted to Know

It's important for casual readers to remember that clinical studies exist to prove whether theories work in real life, because there's still a lot of unknowns, and genetic variability between people.

Treatment for PCP is benzodiazepines/antipsychotics, not ketamine.

Phencyclidine became a reference molecule for many modern drugs currently used.

This article is remarkable incomplete. Why is he only talking about the effect ion the NMDA receptor when ketamine effect much more than that and a lot of stuff we do not know. At higher doses it start effecting other receptors which is why a higher does has seemingly opposite effects.

You can see the K values for the receptors ketamine effects on wikipedia:

https://en.wikipedia.org/wiki/Ketamine#Pharmacology

He does not seem to know ketamine is a D2 receptor agonsit, the same as PCP, yet he mentions it for PCP!

Like most of the "nootropics" people I read they speak only in "vibes".

I've been taking 90mg DXM with my 150mg Bupropion XR for the last few years.

Noticed a moderate improvement. I think NMDA is one of those targets that's flown under the radar, but now is being implicated with all sorts of cognitive processes.

Memantine + half-dose telmisartan (for up to 3 months max) is remarkably effective for treating depression, with no addiction and no withdrawal. One does have to scale up and scale down the doses gradually, and suffer the drowsiness and 10+ point BP reduction, but it works. Do not exceed 3 months because the dopaminergic effect of memantine will catch up by then, and you don't want psychosis from it. One must also avoid common triggers of depression, e.g. fast food, rancid oil, plastic packaging for hot foods, and air pollution from fires. It is also mandatory to engage in strenuous daily exercise, e.g. running, for this regimen to work, although exercise alone doesn't fix it. Of course, someone who hasn't tried it will find it easy to be critical and dismissive, but they're not the ones who need it, and their opinion doesn't matter. The beauty of this solution is that one you're treated, you're cured (assuming you stopped the environmental triggers). There are concrete logical pharmacological, neurological, and physiological reasons for this solution's effectiveness.